一、團隊簡介

南通大學生命科學學院“植物發育與環境適應的分子遺傳調控”團隊。研究方向為植物（作物）重要性狀基因遺傳調控機制解析及育種應用。團隊先后承擔20余項科研項目，發表SCI學術論文80余篇。申請發明專利20余項。

二、團隊負責人簡介

王凱，教授，博士生導師。教育部新世紀優秀人才。先后獲 “閩江學者”特聘教授、“金山學者”特聘教授，福建省引進高層次人才等稱號。曾任國家甘蔗工程技術研究中副主任、副院長等職務。曾獲中華農業科技獎優秀創新團隊獎（等同一等獎）、嚴家顯最高獎教金、江蘇省優秀百篇博士學位論文、江蘇省遺傳學會優秀論文評選特等獎等。主持各類科研項目20項，其中主持國家自然科學基金 6 項、教育部新世紀人才支持計劃、國家重點研發計劃項目，省自然科學基金等項目多項；指導研究生多人獲得省級優秀畢業生和優秀學位論文。現已在Science, Nature Genetics, Genome Res、Plant Cell、PNAS等期刊發表論文70余篇，參編英文著作1部，申請發明專利十余項。現任SCI雜志Frontiers in Plant Science，Chromosome Res編委，美國自然科學基金評委；擔任國際棉花基因組創新研討會會員，中國熱帶作物學會理事，福建省遺傳學會理事。

團隊主持課題：

1. 2022 國家自然科學基金青年基金項目、江蘇省科技計劃項目、江蘇省卓越博后計劃；

2. 2021 國家自然科學基金面上項目；

3. 2019 國家重點研發計劃子課題；

4. 2018 國家自然科學基金面上項目

5. 2017國家自然科學基金海外學者合作研究基金

6. 2015 國家自然科學基金面上項目

7. 2011 國家自然科學基金面上項目

8. 2011教育部新世紀優秀人才支持計劃項目

9. 2008 國家自然科學基金青年科學基金

10. 2008江蘇省自然科學基金

11. 2014閩江學者特聘教授

12. 另外，主持云南省博士工作站及其他合作研究課題十余項。

三、團隊其他成員

韓金磊，博士、校聘副教授。畢業于福建農林大學，從事植物表觀遺傳，基因表達調控等研究。參與完成多項科研項目。以第一作者在國際知名期刊Plant Cell 以及The Plant Journal發表學術論文。主持國家自然科學基金及江蘇省科技計劃項目。

陳琪，博士，畢業于東北林業大學，主要從事植物次生代謝調控及植物逆境生理生態學方面的研究。主持江蘇省高等學校自然科學研究面上項目1項，主持完成南通市科技項目1項，參與國家級項目多項；以第一作者或通訊作者在BMC Plant Biology、Frontiers in Plant Science、Ecotoxicology and Environmental Safety等期刊發表SCI論文12篇。主要承擔植物生物學、植物資源學、中學生物學課程標準與教材分析等生物師范專業主干課程。

寇小兵，博士，校聘副教授。南京農業大學博士（2018）、博士后（2021）。主要從事植物抗逆境脅迫以及生殖發育的分子機制研究。在《Horticulture Research》、《Journal of Agricultural and Food Chemistry》等國際期刊發表SCI文章多篇。主持國家自然科學基金青年基金一項，參與多項國家自然科學基金面上項目。

Teame Gereziher Mehari，博士后，畢業于中國農業科學院棉花研究所，主要從事棉花等作物的遺傳育種研究。

四、團隊主要研究方向

1）植物（作物）重要性狀決定基因的挖掘與分子遺傳調控機制解析；

2）植物基因組結構與演化。

五、發表論著

2023年

1. X. Zhang, Z. Meng, J. Han, H. Khurshid, A. Esh, R. Hasterok, K. Wang, Characterization of meiotic chromosome behavior in the autopolyploid Saccharum spontaneum reveals preferential chromosome pairing without distinct DNA sequence variation, The Crop Journal (2023).

2. W. Ding, Y. Zhu, J. Han, H. Zhang, Z. Xu, H. Khurshid, F. Liu, R. Hasterok, X. Shen, K. Wang, Characterization of centromeric DNA of Gossypium anomalum reveals sequence-independent enrichment dynamics of centromeric repeats, Chromosome Res. 31(2) (2023) 12.

3. K. Wang, H. Zhang, H. Khurshid, A. Esh, C. Wu, Q. Wang, N. Piperidis, Past and recent advances in sugarcane cytogenetics, The Crop Journal 11(1) (2023) 1-8.

4. K. Sun, T.G. Mehari, H. Fang, J. Han, X. Huo, J. Zhang, Y. Chen, D. Wang, Z. Zhuang, A. Ditta, M.K.R. Khan, J. Zhang, K. Wang, B. Wang, Transcriptome, proteome and functional characterization reveals salt stress tolerance mechanisms in upland cotton (Gossypium hirsutum L.), Front. Plant Sci. 14 (2023).

2022年

5. J. Han, D. Lopez-Arredondo, G. Yu, Y. Wang, B. Wang, S.B. Wall, X. Zhang, H. Fang, A.C. Barragan-Rosillo, X. Pan, Y. Jiang, J. Chen, H. Zhang, B.L. Zhou, L. Herrera-Estrella, B. Zhang, K. Wang, Genome-wide chromatin accessibility analysis unveils open chromatin convergent evolution during polyploidization in cotton, Proc. Natl. Acad. Sci. U. S. A. 119(44) (2022) e2209743119.

6. Wang K, Zhang H, Khurshid H, Esh A, Wu C, Wang Q, Piperidis N (2022) Past and recent advances in sugarcane cytogenetics. The Crop Journal，Doi：10.1016/j.cj.2022.08.004

7. K. Wang, D. Xiang, K. Xia, B. Sun, H. Khurshid, A.M.H. Esh, H. Zhang, Characterization of repetitive DNA in Saccharum officinarum and Saccharum spontaneum by genome sequencing and cytological assays, Front. Plant Sci. 13 (2022) 814620.

8. Wang K, Cheng H, Han J, Esh A, Liu J, Zhang Y, Wang B (2022) A comprehensive molecular cytogenetic analysis of the genome architecture in modern sugarcane cultivars. Chromosome Res 30:29-41

9. Xu Z, Chen J, Meng S, Xu P, Zhai C, Huang F, Guo Q, Zhao L, Quan Y, Shangguan Y, Meng Z, Wen T, Zhang Y, Zhang X, Zhao J, Xu J, Liu J, Gao J, Ni W, Chen X, Ji W, Wang N, Lu X, Wang S, Wang K, Zhang T, Shen X (2022) Genome sequence of Gossypium anomalum facilitates interspecific introgression breeding. Plant Communications:100350

10.R. Hasterok, P. Catalan, S.P. Hazen, A.C. Roulin, J.P. Vogel, K. Wang, L.A.J. Mur, Brachypodium: 20 years as a grass biology model system; the way forward?, Trends Plant Sci. 27(10) (2022) 1002-1016.

11.Saleem Ur Rahman, Hamza Ramzan, Haris Khurshid, Niaz Ahmad, Kai Wang, Zahid Mukhtar, G. Raza, Role of Biotechnology for Improvement of Sugarcane, in: R.K. Gaur (Ed.), Omics Approaches for Sugarcane Crop Improvement, CRC Press, Boca Raton, 2022.

12.M. Ji, K. Sun, H. Fang, Z. Zhuang, H. Chen, Q. Chen, Z. Cao, Y. Wang, A. Ditta, M.K.R. Khan, K. Wang, B. Wang, Genome-wide identification and characterization of the CLASP_N gene family in upland cotton (Gossypium hirsutum L.), Peer J 10 (2022) e12733.

13.Tang Y, Chen H, Deng T, Chang Y, Sun K, Ditta A, Khan MKR, Wang K, Wang B (2022) Genome-wide identification and analysis of the GUB_WAK_bind gene family in Gossypium hirsutum. Mol Biol Rep 49:6405-6413

14.Y. Cao, T. Shan, H. Fang, K. Sun, W. Shi, B. Tang, J. Wu, K. Wang, P. Li, B. Wang, Genome-wide analysis reveals the spatiotemporal expression patterns of SOS3 genes in the maize B73 genome in response to salt stress, BMC Genomics 23(1) (2022) 60.

2021年

15.Huang Y, Ding W, Zhang M, Han J, Jing Y, Yao W, Hasterok R, Wang Z, Wang K (2021) The formation and evolution of centromeric satellite repeats in Saccharum species. Plant J106:616-629

16.Wang Q, Yu G, Chen Z, Han J, Hu Y, Wang K (2021) Optimization of protoplast isolation, transformation and its application in sugarcane (Saccharum spontaneum L). The Crop Journal , 9:133-142

17.Meng Z, Wang Q, Khurshid H, Raza G, Han J, Wang B, Wang K (2021) Chromosome Painting Provides Insights Into the Genome Structure and Evolution of Sugarcane. Front. Plant Sci, DOI 10.3389/fpls.2021.731664

18.Wang Y, Wang K (2021) Genome-Wide Identification of DNase I Hypersensitive Sites in Plants. Current protocols, 1:e148

19.Y. Huang, W. Huang, Z. Meng, G.T. Braz, Y. Li, K. Wang, H. Wang, J. Lai, J. Jiang, Z. Dong, W. Jin, Megabase-scale presence-absence variation with Tripsacum origin was under selection during maize domestication and adaptation, Genome Biol. 22(1) (2021) 237.

2020年

20.Han J, Wang P, Wang Q, Lin Q, Chen Z, Yu G, Miao C, Dao Y, Wu R, Schnable JC, Tang H, Wang K (2020) Genome-wide characterization of DNase I-hypersensitive sites and cold response regulatory landscapes in grasses. Plant Cell 32:2457-2473

21.Lin Q, Wang S, Dao Y, Wang J, Wang K (2020) The Arabidopsis thaliana trehalose-6-phosphate phosphatase gene AtTPPI enhances drought tolerance by regulating stomatal apertures. J Exp Bot, DOI 10.1093/jxb/eraa173

22.Hasterok R, Wang K, Jenkins G (2020) Progressive refinement of the karyotyping of Brachypodium genomes. New Phytol, DOI 10.1111/nph.16342

23.Meng Z, Han J, Lin Y, Zhao Y, Lin Q, Ma X, Wang J, Zhang M, Zhang L, Yang Q, Wang K (2020) Characterization of a Saccharum spontaneum with a basic chromosome number of x = 10 provides new insights on genome evolution in genus Saccharum. Theor Appl Genet 133:187-199

24.Huang Y, Chen H, Han J, Zhang Y, Ma S, Yu G, Wang Z, Wang K (2020) Species-specific abundant retrotransposons elucidate the genomic composition of modern sugarcane cultivars. Chromosoma 129:45-55

25.Zhang L, Chen F, Zhang X, Li Z, Zhao Y, Lohaus R, Chang X, Dong W, Ho SYW, Liu X, Song A, Chen J, Guo W, Wang Z, Zhuang Y, Wang H, Chen X, Hu J, Liu Y, Qin Y, Wang K, Dong S, Liu Y, Zhang S, Yu X, Wu Q, Wang L, Yan X, Jiao Y, Kong H, Zhou X, Yu C, Chen Y, Li F, Wang J, Chen W, Chen X, Jia Q, Zhang C, Jiang Y, Zhang W, Liu G, Fu J, Chen F, Ma H, Van de Peer Y, Tang H (2020) The water lily genome and the early evolution of flowering plants. Nature 577:79-84

2019年

26.Wang S, Jin W, Wang K (2019) Centromere histone H3- and phospholipase-mediated haploid induction in plants. Plant Methods 15:42

27.Yu G, Wang J, Miao L, Xi M, Wang Q, Wang K (2019) Optimization of Mature Embryo-Based Tissue Culture and Agrobacterium-Mediated Transformation in Model Grass Brachypodium distachyon. Int J Mol Sci 20

28.Zou J, Mao L, Qiu J, Wang M, Jia L, Wu D, He Z, Chen M, Shen Y, Shen E, Huang Y, Li R, Hu D, Shi L, Wang K, Zhu Q, Ye C, Bancroft I, King GJ, Meng J, Fan L (2019) Genome-wide selection footprints and deleterious variations in young Asian allotetraploid rapeseed. Plant Biotechnol J, 17:1998-2010

29.Lin Q, Yang J, Wang Q, Zhu H, Chen Z, Dao Y, Wang K (2019) Overexpression of the trehalose-6-phosphate phosphatase family gene AtTPPF improves the drought tolerance of Arabidopsis thaliana. BMC Plant Biol 19:381

30.Li Z, Wang K (2019) Genome-Wide Identification of Regulatory DNA Elements in Crop Plants. In: Vaschetto LM (ed) Cereal Genomics: Methods and Protocols. Springer US, New York, NY, pp 85-99

31.Hu  Y, Chen J, Fang L, Zhang Z, Ma W, Niu Y, Ju L, Deng J, Zhao T, Lian J,  Baruch K, Fang D, Liu X, Ruan YL, Rahman MU, Han J, Wang K, Wang Q, Wu  H, Mei G, Zang Y, Han Z, Xu C, Shen W, Yang D, Si Z, Dai F, Zou L, Huang  F, Bai Y, Zhang Y, Brodt A, Ben-Hamo H, Zhu X, Zhou B, Guan X, Zhu S,  Chen X, Zhang T (2019) Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton. Nat Genet 51:739-748

2018年

32.Zhang J, Zhang X, Tang H, Zhang Q, Hua X, Ma X, Zhu F, Jones T, Zhu X, Bowers J, Wai CM, Zheng C, Shi Y, Chen S, Xu X, Yue J, Nelson DR, Huang L, Li Z, Xu H, Zhou D, Wang Y, Hu W, Lin J, Deng Y, Pandey N, Mancini M, Zerpa D, Nguyen JK, Wang L, Yu L, Xin Y, Ge L, Arro J, Han JO, Chakrabarty S, Pushko M, Zhang W, Ma Y, Ma P, Lv M, Chen F, Zheng G, Xu J, Yang Z, Deng F, Chen X, Liao Z, Zhang X, Lin Z, Lin H, Yan H, Kuang Z, Zhong W, Liang P, Wang G, Yuan Y, Shi J, Hou J, Lin J, Jin J, Cao P, Shen Q, Jiang Q, Zhou P, Ma Y, Zhang X, Xu R, Liu J, Zhou Y, Jia H, Ma Q, Qi R, Zhang Z, Fang J, Fang H, Song J, Wang M, Dong G, Wang G, Chen Z, Ma T, Liu H, Dhungana SR, Huss SE, Yang X, Sharma A, Trujillo JH, Martinez MC, Hudson M, Riascos JJ, Schuler M, Chen LQ, Braun DM, Li L, Yu Q, Wang J, Wang K, Schatz MC, Heckerman D, Van Sluys MA, Souza GM, Moore PH, Sankoff D, VanBuren R, Paterson AH, Nagai C, Ming R (2018) Allele-defined genome of the autopolyploid sugarcane Saccharum spontaneum L. Nat Genet 50:1565-1573

33.Sharma A, Song J, Lin Q, Singh R, Ramos N, Wang K, Zhang J, Ming R, Yu Q (2018) Comparative analysis of homologous sequences of Saccharum officinarum and Saccharum spontaneum reveals independent polyploidization events. Front Plant Sci 9:1414

34.Meng Z, Zhang Z, Yan T, Lin Q, Wang Y, Huang W, Huang Y, Li Z, Yu Q, Wang J, Wang K (2018) Comprehensively characterizing the cytological features of Saccharum spontaneum by the development of a complete set of chromosome-specific oligo probes. Front Plant Sci 9:1624

35.Liu S, Xue C, Fang Y, Chen G, Peng X, Zhou Y, Chen C, Liu G, Gu M, Wang K, Zhang W, Wu Y, Gong Z (2018) Global Involvement of Lysine Crotonylation in Protein Modification and Transcription Regulation in Rice. Mol Cell Proteomics 17:1922-1936

36.Li Y, Zuo S, Zhang Z, Li Z, Han J, Chu Z, Hasterok R, Wang K (2018) Centromeric DNA characterization in the model grass Brachypodium distachyon provides insights on the evolution of the genus. Plant J 93:1088-1101

37.Han J, Zhang Z, Wang K (2018) 3C and 3C-based techniques: the powerful tools for spatial genome organization deciphering. Mol Cytogenet 11:21

38.Dong G, Shen J, Zhang Q, Wang J, Yu Q, Ming R, Wang K, Zhang J (2018) Development and applications of chromosome-specific cytogenetic BAC-FISH Probes in S. spontaneum. Front Plant Sci 9:218

2017年：

39.Pan X, Fang Y, Yang X, Zheng D, Chen L, Wang L, Xiao J, Wang XE, Wang K, Cheng Z, Yu H, Zhang W (2017) Chromatin states responsible for the regulation of differentially expressed genes under (60)Co~gamma ray radiation in rice. BMC Genomics 18:778

40.Zhang W, Zuo S, Li Z, Meng Z, Han J, Song J, Pan YB, Wang K (2017) Isolation and characterization of centromeric repetitive DNA sequences in Saccharum spontaneum. Sci Rep 7:41659

41.韓金磊, 吳為人，王凱 (2016). 染色體構象及其研究方法—3C技術. 分子植物育種(12): 3501-3510.

2016：

42.Han J, Masonbrink RE, Shan W, Song F, Zhang J, Yu W, Wang K, Wu Y, Tang H, Wendel JF, Wang K (2016) Rapid proliferation and nucleolar organizer targeting centromeric retrotransposons in cotton. Plant J 88:992-1005

43.Wang K, Yu W (2016) Chromosome Preparation in Rice (Oryza sativa). In: Gary Stacey, Birchler J, Ecker J, Martin C, Stitt M, Zhou J-M (eds) Current Protocols in Plant Biology. John Wiley & Sons, Inc., Hoboken, New Jersey, USA, pp 67-77

44.Wang K, Yu W (2016) In Situ Hybridization in Rice (Oryza sativa). In: Gary Stacey, Birchler J, Ecker J, Martin C, Stitt M, Zhou J-M (eds) Current Protocols in Plant Biology. John Wiley & Sons, Inc., Hoboken, New Jersey, USA, pp 89-106

45.Shan W, Jiang Y, Han J, Wang K (2016) Comprehensive cytological characterization of the Gossypium hirsutum genome based on the development of a set of chromosome cytological markers. Crop Journal 4:256-265

--2015：

46.Han J, Zhou B, Shan W, Yu L, Wu W, Wang K (2015) A and D genomes spatial separation at somatic metaphase in tetraploid cotton: evidence for genomic disposition in a polyploid plant. Plant J 84:1167-1177

47.Gent JI, Wang K, Jiang J, Dawe RK (2015) Stable patterns of CENH3 occupancy through maize lineages containing genetically similar centromeres. Genetics 200:1105-1116

48.Wang K, Wu Y, Zhang W, Dawe RK, Jiang J (2014) Maize centromeres expand and adopt a uniform size in the genetic background of oat. Genome Res 24:107-116

49.Zhang H, Koblizkova A, Wang K, Gong Z, Oliveira L, Torres GA, Wu Y, Zhang W, Novak P, Buell CR, Macas J, Jiang J (2014) Boom-Bust Turnovers of Megabase-Sized Centromeric DNA in Solanum Species: Rapid Evolution of DNA Sequences Associated with Centromeres. Plant Cell 26:1436-1447

50.Cook DE, Bayless AM, Wang K, Guo X, Song Q, Jiang J, Bent AF (2014) Distinct copy number, coding sequence, and locus methylation patterns underlie Rhg1-Mediated soybean resistance to soybean cyst nematode. Plant Physiol 165:630-647

51.Chen Y, Wang Y, Wang K, Zhu X, Guo W, Zhang T, Zhou B (2014) Construction of a complete set of alien chromosome addition lines from Gossypium australe in Gossypium hirsutum: morphological, cytological, and genotypic characterization. Theor Appl Genet 127:1105-1121

52.Wang K, Zhang W, Jiang Y, Zhang T (2013) Systematic application of DNA fiber-FISH technique in cotton. PLoS One, 8:e75674

53.Cook DE, Lee TG, Guo X, Melito S, Wang K, Bayless AM, Wang J, Hughes TJ, Willis DK, Clemente TE, Diers BW, Jiang J, Hudson ME, Bent AF (2012) Copy number variation of multiple genes at Rhg1 mediates nematode resistance in soybean. Science 338:1206-1209

54.Wang K, Zhang W, Cao Y, Zhang Z, Zheng D, Zhou B, Guo W, Zhang T (2012) Localization of high level of sequence conservation and divergence regions in cotton. Theor Appl Genet 124:1173-1182

55.Gong Z, Wu Y, Koblizkova A, Torres GA, Wang K, Iovene M, Neumann P, Zhang W, Novak P, Buell CR, Macas J, Jiang J (2012) Repeatless and repeat-based centromeres in potato: Implications for centromere evolution. Plant Cell 24:3559-3574

56.Zhang H, Phan BH, Wang K, Artelt BJ, Jiang J, Parrott WA, Dawe RK (2012) Stable integration of an engineered megabase repeat array into the maize genome. Plant J 70:357-365

57.Wang K, Guo W, Yang Z, Hu Y, Zhang W, Zhou B, Stelly D, Chen Z, Zhang T (2010) Structure and size variations between 12A and 12D homoeologous chromosomes based on high-resolution cytogenetic map in allotetraploid cotton. Chromosoma 119:255-266

58.Wang K, Yang Z, Shu C, Hu J, Lin Q, Zhang W, Guo W, Zhang T (2009) Higher axial-resolution and sensitivity pachytene fluorescence in situ hybridization protocol in tetraploid cotton. Chromosome Res 17:1041-1050

59.Wang K, Guan B, Guo W, Zhou B, Hu Y, Zhu Y, Zhang T (2008) Completely distinguishing individual A-genome chromosomes and their karyotyping analysis by multiple bacterial artificial chromosome-fluorescence in situ hybridization. Genetics 178:1117-1122

60.Guan B, Wang K, Zhou BL, Guo WZ, Zhang TZ (2008) Establishment of a multi-color genomic in situ hybridization technique to simultaneously discriminate the three interspecific hybrid genomes in gossypium. J Integr Plant Biol 50:345-351

61.Wang K, Guo W, Zhang T (2007) Detection and mapping of homologous and homoeologous segments in homoeologous groups of allotetraploid cotton by BAC-FISH. BMC Genomics 8:178

62.Wang K, Guo W, Zhang T (2007) Development of one set of chromosome-specific microsatellite-containing BACs and their physical mapping in Gossypium hirsutum L. Theor Appl Genet 115:675-682

63.Guo W, Cai C, Wang C, Han Z, Song X, Wang K, Niu X, Wang C, Lu K, Shi B, Zhang T (2007) A microsatellite-based, gene-rich linkage map reveals genome structure, function and evolution in Gossypium. Genetics 176:527-541

64.Wang K, Song X, Han Z, Guo W, Yu JZ, Sun J, Pan J, Kohel RJ, Zhang T (2006) Complete assignment of the chromosomes of Gossypium hirsutum L. by translocation and fluorescence in situ hybridization mapping. Theor Appl Genet 113:73-80

65.Song X, Wang K, Guo W, Zhang J, Zhang T (2005) A comparison of genetic maps constructed from haploid and BC1 mapping populations from the same crossing between Gossypium hirsutum L. and Gossypium barbadense L. Genome 48:378-390  

六、招聘啟事

因研究工作需要，本團隊誠招作物遺傳育種、遺傳學、生物信息學等相關專業博士后或博士畢業生。

應聘資格：

1．熱愛科研，工作積極主動，態度嚴謹，責任心強，具備良好的團隊合作精神。

2．具備獨立開展科研的能力；以第一作者身份發表過SCI論文。

相關待遇：詳見南通大學人事處網站https://rsc.ntu.edu.cn/xgdy/list.htm

有意者請將個人簡歷、導師推薦信發電子郵箱：kaiwang92@sina.com（郵件標題注明：應聘某某崗位+本人姓名 ）

聯系人：王老師、韓老師

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https://smkxxy.ntu.edu.cn/2022/1024/c2349a201055/page.htm

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