一、中心簡介
首都醫學科學創新中心（簡稱創新中心）是北京市新成立的具有獨立法人資格的新型研發機構。創新中心以推動醫學科學發展、改善人類健康為目標，開展生物醫學研究，致力于提升醫學科學創新與成果轉化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學家及其科研團隊，與首都醫學教育和科學研究優質資源緊密合作，打造多學科交叉融合的科研平臺，綜合自由探索、醫學目標導向、有組織科研等途徑，實踐新型科研模式和體制機制，逐步推進醫教研產的深度融合，培養適應醫學科學創新發展的優秀人才。
二、實驗室介紹
郭鵬飛研究員先后在江南大學、北京大學/北京生命科學研究所獲得學士
三、實驗室研究方向
實驗室將綜合利用各類模式生物系統，結合功能基因組篩選、細胞生物學、蛋白質組學、單細胞測序、代謝組學、生物信息學等手段開展以下課題研究：
1.通過全基因組篩選，鑒定調控組織生長和器官大小的關鍵基因，揭示器官發育和組織再生背后的遺傳網絡和信號通路。
2.研究組織力學在調控組織生長中的作用，特別是機械力和組織的機械性質如何影響細胞行為。此外，我們還研究腫瘤微環境的力學特性如何影響腫瘤生長和免疫反應。
3.研究Hippo信號通路在正常發育過程中的作用及其失調如何導致先天性發育疾病，特別是神經發育疾病。
四、代表性文章
Science.2024.385(6709):eadf4478.PMID: 39116228.
eLife.2019.22:8:e38843.PMID: 30901309.
PNAS.2010.107(42):18016–18021.PMID: 20921409.
五、崗位信息
01科研助理
1）主要職責
1.獨立或協助團隊開展課題研究；
2.管理和維護實驗室日常工作和行政事務。
2）任職要求
1.大學本科學歷及以上，生物學、基礎醫學等相關專業；
2.掌握常規分子克隆、細胞培養或動物實驗的操作及原理，有實驗室研究工作經歷優先；
3.具備良好的溝通能力和團隊協作能力；
4.具備良好的英語讀寫和日常交流能力。
02博士后
1）主要職責
1.在課題組長指導下獨立開展研究工作；
2.協助指導研究生工作以及撰寫論文或基金申請。
2）任職要求
1.具有生命科學或其他相關生物醫學領域的研究背景，即將獲得博士學位或已獲得博士學位（原則上不超過2年）；
2.有小鼠腫瘤模型、發育生物學、全基因組CRISPR篩選或生物信息學背景者優先考慮；
3.以第一作者身份在領域內主流期刊上發表過或即將發表研究論文，能夠獨立開展研究工作，具有科研熱情和嚴謹的科研態度；
4.具備良好的英語讀寫和日常交流能力，能夠使用英文撰寫論文。
六、福利待遇
1.根據應聘者的工作經驗和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險一金、帶薪年假、體檢和補充醫療保險等；
3.支持個人職業發展，提供必要的工作相關專業培訓。
七、申請方法
應聘者請將個人簡歷、研究興趣或計劃，以及2-3名推薦人（僅限博士后應聘）的姓名及聯系方式，以及其他能證明科研能力的相關電子文件發送到郵箱
guopengfei@cimrbj.ac.cn，請【點擊下方“立即投遞/投遞簡歷”，即刻進行職位報名】，郵件主題請注明“應聘者名字+具體應聘職位”。
聯系人：
聯系地址：北京市豐臺區右安門外西頭條10號-首都醫學科學創新中心
本招聘長期有效，至招聘到合適人選為止。
ABOUT CIMR
The Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research.The CIMR is located at the main campus of the
Laboratory Introduction
The Guo laboratory at CIMR works on uncovering the molecular and genetic mechanisms that regulate tissue growth and organ size control, as well as understanding how dysregulation of these processes contributes to human diseases.
Major Research Projects
The Guo lab will use various model systems and integrate cutting-edge techniques in genetics, cell biology, and bioinformatic, with the aims of elucidating fundamental biological principles and identifying novel pathways involved in disease pathogenesis.
a.Conducting genome-wide screening in Drosophila and mouse models to identify key genes that regulate tissue growth and organ size.
b.Investigating the role of tissue mechanics in regulating tissue growth and how physical forces and mechanical properties influence cellular behavior.Additionally, we explore how the tumor microenvironment’s physical properties affect tumor growth and immune response.
c.Investigating the role of the Hippo signaling pathway in normal developmental processes and how its disruption contributes to congenital developmental diseases, with a particular focus on neurodevelopmental disorders.
Representative Publications
Science.2024.385(6709):eadf4478.PMID: 39116228.
eLife.2019.22:8:e38843.PMID: 30901309.
PNAS.2010.107(42):18016–18021.PMID: 20921409.
Open Positions
Research Assistant
Main Responsibilities
a.Conducting research projects independently or in collaboration with other lab members.
b.Getting involved in lab data analysis and management.
Qualifications
a.B.S or higher degree in biology, basic medical science and other relevant majors is required.
b.Research experience in molecular biology, biochemistry, cell biology and/or mouse studies is preferred.
c.Self-motivated researcher with good communication skill and teamwork ability.
d.Proficient in English reading, writing, and daily communication.
Postdoctoral Researcher
Main Responsibilities
a.Conducting research projects independently.
b.Assisting PI to mentor graduate students, write grant proposals and manuscripts.
Qualifications
a.Backgrounds in biology or biomedical fields.Either about to obtain a Ph.D.or recently obtained a Ph.D.degree (ideally within the last 2 years).
b.Candidates with experience in mouse tumor models, developmental biology, or genome-wide CRISPR screening are preferred.
c.Proven ability to conduct independent research, demonstrated by a first-author publication in a reputable journal in the field (or a paper accepted for publication).
d.Proficient in English reading, writing, and daily communication.Capable of writing papers in English.
Welfare Treatment
a.Competitive salary based on the job applicant's work experience and abilities (salary negotiable).
b.Social insurance, paid annual leave, physical examination and supplementary medical insurance, etc.
c.Supporting personal career development and providing necessary job related professional training.
How to apply
To apply, please send personal resume, research interest or plan, the names and contacts of 2-3 referees (for postdoc position only) and other materials demonstrating research capabilities to guopengfei@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.
Contact person: Pengfei Guo
This recruitment is valid for the long term until a suitable candidate is recruited.
為防止簡歷投遞丟失請抄送一份至：boshijob@126.com（郵件標題格式：應聘職位名稱+姓名+學歷+專業+中國博士人才網）
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