瑞典烏普薩拉大學2023年招聘博士后（細菌學：快速抗菌藥敏檢測的開發）

烏普薩拉大學（英文：Uppsala University），是坐落于瑞典古都烏普薩拉市的一所歐洲知名綜合研究型大學，是擁有500余年歷史的北歐地區的第一所大學。該校是科英布拉集團、歐洲研究型大學協會、昴宿星大學聯盟、瑞日Mirai成員。

Postdoc in bacteriology with focus on development of rapid antimicrobial susceptibility testing

Uppsala University

Postdoc in bacteriology with focus on development of rapid antimicrobial

susceptibility testing

Published: 2023-02-10

Uppsala University is a comprehensive research-intensive university with a strong international standing. Our ultimate goal is to conduct education and research of the highest quality and relevance to make a long-term difference in society. Our most important assets are all the individuals whose curiosity and dedication make Uppsala University one of Sweden's most exciting workplaces. Uppsala University has over 54,000 students, more than 7,500 employees and a turnover of around SEK 8 billion.

Electrification and digitalisation are among the largest areas for the future sustainable societies. The Department of Electrical Engineering conducts successful research and education in the areas - renewable energy sources, electric vehicles, industrial IoT, 5G communication and wireless sensor networks as well as smart electronic sensors and medical systems. The Department of Electrical Engineering is an international workplace with around 130 employees that all contribute to important engineering, energy and health challenges at the Ångström Laboratory.

The positions will be atProf. Zhen Zhang's group in the Solid-State Electronics division, the Department of Electrical Engineering.The multidisciplinary postdoc project will be in close collaboration with Prof. SannaKoskiniemi at the Department of Cell and Molecular Biology, Uppsala Biomedical Centre, Uppsala University.

Read more about our benefits and what it is like to work at Uppsala University

Project description Rapid antibiotic susceptibility tests (rASTs) are highly desired in modern clinical practice for quick selection of right antibiotics to treat infectious diseases at the early but critical stage. However, currently available testing methods normally require growth of bacteria into colonies, which usually take more than two days to accomplish a task. They are, therefore, not satisfactory for practical needs that require fast answers. Moreover, these methods are not applicable for slow-growing bacteria, or samples containing sub-populations of slow- or non-growing bacteria which can resume growth after the antibiotic attack. To understand if and how the sub- population of slow-/non-growing bacteria causes failure in infection treatments, rASTs at the single cell level is required. To address these challenges, our project aims at developing a novel Silicon (Si) chip based all-electrical testing platform to achieve rAST at single cell level. The success of this project will potentially provide a low-cost and rapid ASTs platform for effective infection treatments. It could also help to accelerate the development of new antibiotic drugs in the pharmaceutical industry.

Duties The applicant is expected to drive the bacteriological side of the project. Duties include general microbiology and molecular biology work in the laboratory as well as experimental work in the clean room facility with testing the devices being developed. Bioinformatic analyses of bacterial genomes to identify metabolic pathways are included. The project requires extensive knowledge about bacterial metabolism and physiology, so the duties include literature searches as well as oral presentations and writing/editing of scientific papers.

Requirements PhD degree in microbiology, molecular biology or similar or a foreign degree equivalent to a PhD degree.

The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.

The candidate is expected to be able to work independently and to have a strong interest in antibiotic resistance, tolerance and bacterial metabolism. In addition, the candidate is expected to take own initiatives as well as to collaborate with colleagues both within and outside of the research group. The position is in an international context so good oral and written communication skills in English are essential. Finally, significant weight will be given to personal suitability such as; analytical and organizational skills, personal maturity, ability to work with others, take initiatives, and to show good judgement.

Additional qualifications Documented ability of work relating to bacterial metabolism is meriting

About the employment The employment is a temporary position of 2 years according to central collective agreement. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala

For further information about the position, please contact: Professor Zhen Zhang, telephone +46 18-471 3131, zhen.zhang@angstrom.uu.se and associate professor SannaKoskiniemi, telephone: +46 70 7607616, email: sanna.koskiniemi@icm.uu.se

Please submit your application by 15th of March, 2023, UFV-PA 2023/568.

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Submit your application through Uppsala University's recruitment system.

Placement: Department of Electrical Engineering

Type of employment: Full time , Temporary position

Pay: Fixed salary

Number of positions: 1

Working hours: 100%

Town: Uppsala

County: Uppsala län

Country: Sweden

Union representative: SekoUniversitetsklubben seko@uadm.uu.se ST/TCO tco@fackorg.uu.se Saco-rådet saco@uadm.uu.se

Number of reference: UFV-PA 2023/568

Last application date: 2023-03-15

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