招聘簡介：

　　賓夕法尼亞大學佩雷爾曼醫(yī)學院楊曉魯博士的實驗室有兩個博士后職位。實驗室研究神經退行性疾病和癌癥。目前的項目主要集中在兩個方面：

　　（1）蛋白質質量控制與神經退行性疾病的發(fā)病機制。我們的實驗室最近在動物細胞中發(fā)現(xiàn)了一種新的蛋白質質量控制系統(tǒng)，它具有多功能和強大的功能。我們正在研究這個系統(tǒng)的作用機制及其在老年和神經退行性疾病（包括阿爾茨海默病、帕金森病、ALS和多谷氨酰胺疾病）中的作用。

　　（2）腫瘤抑制因子p53和腫瘤細胞代謝。我們對卓越的腫瘤抑制因子p53的功能和調控很感興趣。我們最近的研究結果顯示p53在調節(jié)代謝中起著重要作用。我們正在繼續(xù)研究p53作為各種代謝活動的前哨和調節(jié)器的功能。我們也在研究促進腫瘤發(fā)生和發(fā)展的代謝變化。

　　英文原文：

　　Two postdoctoral positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The lab studies neurodegenerative diseases and cancer. Current projects focus on two areas:

　　(1) Protein quality control and the pathogenesis of neurodegenerative diseases. Our lab recently identified a novel protein quality control system in animal cells that is multifunctional and powerful. We are investigating the mechanism of action of this system and its role in aging and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, ALS, and polyglutamine diseases.

　　(2) The tumor suppressor p53 and tumor cell metabolism. We are interested in the functions and regulation of preeminent tumor suppressor p53. Our recent results revealed an important role for p53 in modulating metabolism. We are continuing to investigate the function of p53 as both a sentinel and a regulator for various metabolic activities. We are also studying metabolic alterations that drive tumor initiation and progression.

　　For more information on the laboratory and its research, please see the following publications and website:

　　Nature Communications 9(1): 1223, 2018

　　Nature Communications 9(1): 4683, 2018

　　Cell Reports 18(13): 3143-3154, 2017

　　Molecular Cell 55: 15-30, 2014 (cover article)

　　Nature 493: 689-93, 2013

　　Nature Cell Biology 15: 991-1000, 2013 (cover article)

　　Nature Cell Biology 13: 310-6, 2011 (cover article)

　　Molecular Cell 37: 668-78, 2010 (cover article)

　　Cell 133: 415-26, 2008

　　Molecular Cell, 31: 415-21, 2008

　　http://www.med.upenn.edu/apps/faculty/index.php/g20000320/p20138

　　Successful candidates should have an expected or recently earned Ph.D. degree, a strong record of scientific productivity, and extensive experience in a related field, including but not limited to molecular biology, biochemistry, cell biology, cancer, metabolism, neuroscience, and cell/mouse models of neurodegenerative diseases.

　　To apply, please send a cover letter, curriculum vitae, and the names and addresses of three references to:

　　Xiaolu Yang, PhD

　　Professor, Department of Cancer Biology

　　Investigator, Abramson Family Cancer Research Institute

　　Member, Penn Medicine Neuroscience Center

　　Perelman School of Medicine

　　University of Pennsylvania

　　654 BRB 2/3, 421 Curie Blvd

　　Philadelphia, PA 19104-6160

　　xyang@pennmedicine.upenn.edu

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